The risk of surgical site infection is a concern for all aesthetic surgeons. Steps to reduce the infection risk and improve patient outcomes begin with vigilance to proper and adherence to aseptic surgical techniques and the current infection control guidelines. If surgical site infection develops, adequate medical and surgical treatment should be implemented. Particularly, the aesthetic surgeons should be aware of the impact of biofilms on delayed wound healing. The biofilm containing several types of bacteria exhibits higher resistance to the commonly-use antibiotics and the host immune responses, so eradicating biofilms is critical for the effective treatment of non-healing infected wounds. Moreover, special concerns should be cautioned when implants are involved in the surgical site infection. Since surgical site infection is one of the most untoward complications for patients seeking aesthetic surgery, every aesthetic surgeon should be aware of its appropriate prevention and management strategy.